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中文名：盐酸多柔比星，盐酸阿霉素
英文名：Doxorubicin HCL,Adriamycin HCL,Doxorubicin hydrochloride
分子量：579.99
分子式：C27H30ClNO11
CAS No.： 25316-40-9
性状描述:外观为桔红色针状结晶熔点204-205℃。溶于水和醇，不溶于丙酮、苯、氯仿、乙醚。
由松链丝菌浅灰色变株(Str.Peucetius var.Caesius)的培养液提取而得。本品化学结构与柔红霉素类似，因此可以由柔红霉素化学转化而制得。目前已可化学全合成。
药理作用：可穿透进入细胞与肿瘤细胞ＤＮＡ交叉，联结，抑制ＤＮＡ复制，并阻断ＲＮＡ聚合酶的作用，抑制ＲＮＡ的合成；其细胞毒作用与自由基形成，与肿瘤细胞膜结合和破快细胞膜有关。
适应症： 用于治疗急性淋巴细胞白血病、急性粒细胞性白血病、霍奇金病和非霍奇金病淋巴瘤、乳腺癌、肺癌、卵巢癌、软组织肉瘤、成骨肉瘤、横纹肌肉瘤、肾母细胞瘤、神经母细胞瘤、膀胱瘤、甲状腺瘤、绒毛膜上皮癌、前列腺癌、睾丸癌、胃癌、肝癌等。
Sigma相关资料如下：
Sigma D1515 Doxorubicin hydrochloride ≥98% (TLC)
Synonym: Adriamycin® hydrochloride, DOX, Hydroxydaunorubicin hydrochloride
CAS Number: 25316-40-9
Linear Formula: C27H29NO11 • HCl
Molecular Weight: 579.98
Beilstein Registry Number: 4229251
EC Number: 246-818-3
Description
Frequently Asked Questions Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA;1 Properties.2,3
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
Legal Information Adriamycin is a registered trademark of Farmitalia Carlo Erba S.R.L.
性质
assay ≥98% (TLC)
mp 216 °C (dec.)(lit.)
storage temp. 2-8°C
Solubility (Color): Orange to Red
Solubility (Turbidity): Clear 50 mg/mL, H2O |