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17-NHS-ALA-GA
GA analog for coupling of NH2-containing molecules
17-NHS-ALA-GA is an NHS (N-hydroxysuccinimide) activated geldanamycin analog designed for easy coupling of NH2-containing molecules. NHS coupling forms a chemically stable amide bond with ligands containing primary amino groups such as small proteins and peptides. Thus, 17-NHS-ALA-GA can be used for conjugation of GA to a monoclonal antibody similarly to 17-GMB-APAGA3,4. It can also be used to perform affinity chromatography to purify GA binding proteins such as Hsp90.
Formula: C44H84N4O12
Molecular weight: 841
Solubility: Chloroform, DMSO, methanol (10 mg/ml) |