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Bisindolylmaleimide I
2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, GF 109203X, Gö 6850
A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα-, βI-, βII-, γ-, δ-, and ε- isozymes. Potently inhibits GSK-3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK-3β immunoprecipitates (IC50 = 170 nM). May inhibit protein kinase A at a much higher concentration (IC50 = 2 µM). A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203293) in anhydrous DMSO is also available.
产品信息
Form Deep orange solid
Primary Target PKC
Secondary target GSK-3 (IC50 = 360 nM), GSK-3β (IC50 = 170 nM), PKA (Ki = 2 mM)
Protect from Light 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC
Chemical formula C25H24N4O2
CAS number 133052-90-1
Declaration Sold under license of U.S. Patent 5,380,746.
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |