产品编号：15386-500
产品名称：Ikarugamycin
供应商：Cayman
规格： 500 μg
目录价：2226
Ikarugamycin
Cayman Chemical Item Number 15386
(CAS 36531-78-9)
Description
Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity.1 It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases.2 It also was shown to significantly inhibit oxidized low-density lipoprotein-induced accumulation of cholesteryl esters in macrophages at 1-4 μM.3 Additionally, ikarugamycin is used to inhibit clathrin-coated pit-mediated endocytosis.4
Formal Name(2R,3R,7Z,14S,19E)-3-ethyl-2,3,3aS,5aR,5bS,6,10,11,12,13,14,15,20aS,21,21aR,21bR-hexadecahydro-22-hydroxy-2-methyl-14,17-metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione
CAS Number36531-78-9
Molecular FormulaC29H38N2O4
Formula Weight478.6
FormulationA white solid
Purity≥99%
Stability2 years
Storage-20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILESCopy O=C(C1=C(O)[C@H](CCCN2)NC1=O)/C=C/[C@@H]3C[C@@]4([H])[C@@](C=C[C@]5([H])[C@]4([H])C[C@@H](C)[C@H]5CC)([H])[C@H]3C/C=C\C2=O
InCHI CodeCopy 1S/C29H38N2O4/c1-3-18-16(2)14-22-20(18)10-11-21-19-6-4-8-26(33)30-13-5-7-24-28(34)27(29(35)31-24)25(32)12-9-17(19)15-23(21)22/h4,8-12,16-24,34H,3,5-7,13-15H2,1-2H3,(H,30,33)(H,31,35)/b8-4-,12-9+/t16-,17-,18-,19+,20+,21-,22+,23+,24+/m1/s1
InCHI KeyCopy WSUGGLXIPUHOSG-QOMLVTEJSA-N